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1994-10-25
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Document 3229
DOCN M94A3229
TI Lipid peroxidation role in formation of immunodeficiency in HIV-1
infection.
DT 9412
AU Pastushenkov V; Mitin Y; Karpischenko A; Ivanov G; Military Medical
Academy, St. Petersburg, Russia.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):123 (abstract no. PA0113). Unique
Identifier : AIDSLINE ICA10/94369346
AB OBJECTIVE: To study the influence of lipid peroxidation on lymphocyte
function and nuclear chromatin degradation in the course of
immunodeficiency progression in HIV-1 infection. METHODS: 37 HIV-1
infection patients (WB and ELISE) persons were investigated. T and B
cells subsets were counted by cytofluorimetric assay. Biochemical
criteria of lymphocyte function were: activity of manthine oxidase, NAD
and NADPH oxidase, and the enzymes of glutathione metabolism. Chromatin
degradation products (polydexy nucleoproteides) and the intensity of DNA
single-strand breaks were studied by spectrophotometric assay. Lipid
peroxidation intensity was assessed by the determination of
thiobarbituric acid--reactive substances. RESULTS: Lipid peroxidation
intensity in HIV-1 patients' lymphocytes was significantely increased
compared to control. Its dynamics was parallel to that of chromatin
degradation process and inversely correlated with the parameters of
lymphocytes function. CONCLUSIONS: Lipid peroxidation takes an important
part in the development of lymphocyte dysfunction and, hence, of immune
deficiency state in HIV-1 infection.
DE Acquired Immunodeficiency Syndrome/*BLOOD/*IMMUNOLOGY B-Lymphocyte
Subsets/*IMMUNOLOGY/METABOLISM Glutathione/BLOOD Human *HIV-1 *Lipid
Peroxidation Multienzyme Complexes/BLOOD NADH, NADPH
Oxidoreductases/BLOOD T-Lymphocyte Subsets/*IMMUNOLOGY/METABOLISM
Xanthine Oxidase/BLOOD MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).